文献类型：期刊文献

英文题名：Integration of chemotherapy and phototherapy based on a pH/ROS/NIR multi-responsive polymer-modified MSN drug delivery system for improved antitumor cells efficacy

作者：Xu, Jun[1,2];Chen, Miaoxin[1,2];Li, Mengli[1,2];Xu, Shouhong[1,2];Liu, Honglai[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2023

卷号：663

外文期刊名：COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

收录：;EI(收录号：20230713572542);WOS:【SCI-EXPANDED(收录号:WOS:000997728200001)】；

基金：Acknowledgements This work was supported by the National Natural Science Foundation of China (No. 22078087) .

语种：英文

外文关键词：Drug delivery system; Mesoporous silica nanoparticles; Multi-responsive

摘要：Due to the difference of the intracellular microenvironment between tumor and normal cells, many stimuliresponsive drug carriers have been developed for precise drug delivery and improved treatment effect. In this paper, a multi responsive drug delivery system based on mesoporous silica nanoparticle (MSN) was prepared. A pH/ROS-sensitive polymer was designed and used to attach to the MSN surface, which acted as a smart nanovalve to prevent premature leakage of drugs. The carrier has been proved to release drugs selectively in simulated tumor microenvironment with lower pH and higher ROS content. And, by co-loading a photosensitizer with antitumor drug, the carrier could produce exogenous ROS under the near-infrared light irradiation, resulting in much quicker removing of the polymer and more drug release. Furtherly, the antitumor effect was evaluated by CCK-8 assay using normal and tumor liver cells. In short, the results of drug release and cell experiments both showed that the carriers had excellent anti-tumor cells effects.