文献类型：期刊文献

英文题名：Highly Discriminating Photorelease of Anticancer Drugs Based on Hypoxia Activatable Phototrigger Conjugated Chitosan Nanoparticles

作者：Lin, Qiuning[1];Bao, Chunyan[1];Yang, Yunlong[1];Liang, Qiannan[1];Zhang, Dasheng[1];Cheng, Shuiyu[1];Zhu, Linyong[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2013

卷号：25

期号：14

起止页码：1981

外文期刊名：ADVANCED MATERIALS

收录：;EI(收录号：20131616210860);WOS:【SCI-EXPANDED(收录号:WOS:000317368500004)】；

基金：This research was supported by the NSFC (21173078, 20903039), Shanghai Sci. Tech. Comm. (11JC1403300), 973 Project (2013CB733700), and the Fundamental research Funds for the Central University.

语种：英文

外文关键词：drug release; tumour hypoxia; activatable phototrigger; two-photon NIR; coumarin

摘要：An ultimately selective photorelease system of chitosan-nanoparticles is constructed. Only under unique aspects of tumor-hypoxia physiological conditions, the preliminary locked phototrigger is unlocked by biological reduction to enable the release of the caged drug either by visible light or two-photon near-IR (NIR) excitation. This approach provides a highly discriminating photorelease of anticancer drug to hypoxic tumor cells, but not to healthy normal cells.