文献类型：期刊文献

英文题名：Programmable Electrofabrication of Porous Janus Films with Tunable Janus Balance for Anisotropic Cell Guidance and Tissue Regeneration

作者：Lei, Miao[1];Qu, Xue[1];Liu, Huan[1,2];Liu, Yi[2];Wang, Shijia[1];Wu, Shang[2];Bentley, William E.[2];Payne, Gregory F.[2];Liu, Changsheng[1]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[2]Inst Biosci & Biotechnol Res & Fischell, Dept Bioengn, 5115 Plant Sci Bldg, College Pk, MD 20742 USA

年份：2019

卷号：29

期号：18

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20191106627436);WOS:【SCI-EXPANDED(收录号:WOS:000471330500018)】；

基金：This work was supported by the National Natural Science Foundation of China (51621002, 31330028, and 51573047), the 111 project (B14018), the Science and Technology Innovation Project of Shanghai Science and Technique Committee (18441908300), and United States National Science Foundation (DMREF-1435957). Animal experiments were performed in strict accordance with National Institutes of Health (NIH) guidelines for the care and use of laboratory animals (NIH Publication no. 85-23 Rev. 1985) and all procedures were approved by the Research Center for Laboratory Animals of Shanghai University of Traditional Chinese Medicine (Shanghai, China).

语种：英文

外文关键词：electrofabrication; guided bone regeneration; Janus balance; Janus film; pore structures; salt effect

摘要：Janus films with controlled pore structures can be particularly important in diverse applications. There remains a challenge for simple, rapid, and scalable fabrication methods to control Janus balance (JB) including the thickness of the individual face as well as porosity and pore size. Here the electrofabrication of a porous Janus film with controlled Janus balance from aminopolysaccharide chitosan under the salt effect is reported. Sequential deposition of chitosan under programmable salt environment and electrochemical conditions enables construction of Janus films with precisely controlled Janus balance. Bioactive partially soluble calcium phosphate (CaP) salts can also generate porous structure in Janus film. It is specifically reported that a chitosan/hydroxyl apatite (HAp) composite Janus film can serve as an effective scaffold for guided bone regeneration. The dense layer functions to provide mechanical support and serves as a barrier for fibrous connective tissue penetration. The porous composite layer functions to provide the microenvironment for osteogenesis. In vivo studies using a rat calvarial defect model confirm the beneficial features of this Janus composite for guided bone regeneration. These results suggest the potential of electrofabrication as a simple and scalable platform technology to tune the self-organization of soft matter for a range of emerging applications.