文献类型：期刊文献

英文题名：Redox-Controlled Voltage Responsive Micelles Assembled by Noncovalently Grafted Polymers for Controlled Drug Release

作者：Yuan, Zhenyu[1];Wang, Jie[1];Wang, Yiming[1];Zhong, Yujie[1];Zhang, Xinsheng[1];Li, Li[1];Wang, Junyou[1];Lincoln, Stephen F.[2];Guo, Xuhong[1,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]Univ Adelaide, Sch Chem & Phys, Adelaide, SA 5005, Australia;[3]Shihezi Univ, Engn Res Ctr Mat Chem Engn Xinjiang Bingtuan, Shihezi 832000, Xinjiang, Peoples R China

年份：2019

卷号：52

期号：4

起止页码：1400

外文期刊名：MACROMOLECULES

收录：;EI(收录号：20191006594429);WOS:【SCI-EXPANDED(收录号:WOS:000460199600005)】；

基金：We gratefully thank NSFC Grants 51403062, 51273063, and 21476143, the Fundamental Research Funds for the Central Universities, 111 Project Grant (B08021), and Firmenich Aromatics (China) Co., Ltd., for financial support of this work. We also thank Prof. Martien A. Cohen Stuart for polishing the manuscript.

语种：英文

外文关键词：Iron compounds - Cyclic voltammetry - Organometallics - Targeted drug delivery - Micelles - Drug interactions - Controlled drug delivery

摘要：Voltage responsive micelles prepared from noncovalently grafted amphiphilic polymers were reported. The noncovalent amphiphilic polymers were prepared through the host-guest interaction between beta-cyclodextrin (beta-CD) grafted dextran (Dex-CD) and ferrocene (Fc) terminated poly(epsilon-caprolactone) (PCL-Fc). Because of the presence of Fc groups, the inclusion complex between Fc and beta-CD can be reversibly controlled by an external stimulating voltage, leading to reversible formation and disassembly of the micelles. The occurrence of the inclusion complex between Fc and beta-CD was confirmed by cyclic voltammetry (CV) and the 2D NOESY spectrum. Furthermore, meloxicam was selected as a model drug to test the controlled release performance of these voltage responsive micelles. It was found that the release rate and the final cumulative release amount of meloxicam can be effectively controlled by the external voltage, which may be of use in controlled drug delivery.