文献类型：期刊文献

英文题名：Enlisting a Traditional Chinese Medicine to tune the gelation kinetics of a bioactive tissue adhesive for fast hemostasis or minimally invasive therapy

作者：Tan, Haoqi[1];Jin, Dawei[2];Sun, Junjie[1];Song, Jialin[1];Lu, Yao[1];Yin, Meng[2];Chen, Xin[1];Qu, Xue[1];Liu, Changsheng[1]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Mat Sci & Engn, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Sch Med, Dept Cardiothorac Surg, 1678 Dong Fang Rd, Shanghai 200127, Peoples R China

年份：2021

卷号：6

期号：3

起止页码：905

外文期刊名：BIOACTIVE MATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000606983400025)】；

基金：This work was supported by National Natural Science Foundation of China (grant number: 31922041, 51621002, 11932012 and 21875066), the science and technology innovation project of Shanghai Science and Technique Committee (18441908300), the Fundamental Research Funds for the Central Universities (SLD 00202006, JKVD12001032, JKVD12001002, 50321041916015).

语种：英文

外文关键词：Injectable tissue adhesive; Gelation time; Borax; Rapid hemostasis; Minimally invasive delivery

摘要：Gelation kinetics is important in tailoring chemically crosslinked hydrogel-based injectable adhesives for different applications. However, the regulation of gelation rate is usually limited to varying the gel precursor and/or crosslinker concentration, which cannot reach a fine level and inevitably alters the physical properties of hydrogels. Amidation reactions are widely used to synthesize hydrogel adhesives. In this work, we propose a traditional Chinese medicine (Borax)-input strategy to tune the gelation rate of amidation reaction triggered systems. Borax provides an initial basic buffer environment to promote the deprotonation process of amino groups and accelerate this reaction. By using a tissue adhesive model PEG-lysozyme (PEG-LZM), the gelation time can be modulated from seconds to minutes with varying Borax concentrations, while the physical properties remain constant. Moreover, the antibacterial ability can be improved due to the bioactivity of Borax. The hydrogel precursors can be regulated to solidify instantly to close the bleeding wound at emergency. Meanwhile, they can also be customized to match the flowing time in the catheter, thereby facilitating minimally invasive tissue sealing. Because this method is easily operated, we envision Borax adjusted amidation-type hydrogel has a promising prospect in clinical application.