文献类型：期刊文献

英文题名：Cinchona alkaloid thiourea mediated asymmetric Mannich reaction of isocyanoacetates with isatin-derived ketimines and subsequent cyclization: enantioselective synthesis of spirooxindole imidazolines

作者：Zhao, Mei-Xin[1,2,3];Jing, Lei[1,2];Zhou, Hao[1,2];Shi, Min[1,2,4]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China;[4]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

年份：2015

卷号：5

期号：92

起止页码：75648

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20153701267854);WOS:【SCI-EXPANDED(收录号:WOS:000361120000081)】；

基金：We gratefully acknowledge financial support from the National Natural Science Foundation of China (21072056, 21272067) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Enantioselectivity

摘要：We report the organocatalyzed asymmetric Mannich reaction of isocyanoacetates with isatin derived ketimines in good yields along with high stereoselectivities. The subsequent organocatalyzed cyclization of Mannich adducts is also investigated, emerging as a promising strategy for the synthesis of optically active spirooxindole imidazolines.