文献类型：期刊文献

英文题名：Enantioselective Synthesis of Spirooxindole Enols: Regioselective and Asymmetric [3+2] Cyclization of 3-Isothiocyanato Oxindoles with Dibenzylidene Ketones

作者：Du, Dan[1];Jiang, Yu[2,3];Xu, Qin[2,3];Li, Xiao-Ge[1];Shi, Min[1,2,3]

机构：[1]Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China;[2]East China Univ Sci & Technol, Key Lab Adv Mat, Meilong Rd 130, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Inst Fine Chem, Meilong Rd 130, Shanghai 200237, Peoples R China

年份：2016

卷号：5

期号：4

起止页码：311

外文期刊名：CHEMISTRYOPEN

收录：;EI(收录号：20231113713974);WOS:【SCI-EXPANDED(收录号:WOS:000382743900005)】；

基金：This work was supported by the Joint NSFC-ISF Research Program, jointly funded by the National Natural Science Foundation of China and the Israel Science Foundation. We are also grateful for financial support from the National Basic Research Program of China ((973)-2015CB856603) and the National Natural Science Foundation of China (20472096, 21372241, 21361140350, 20672127, 21421091, 21372250, 21121062, 21302203, 20732008, and 21572052).

语种：英文

外文关键词：[3+2] cyclization; asymmetric organocatalysis; regioselectivity; stereoselectivity; spirooxindole enols

摘要：A novel cinchona-alkaloid-derived organocatalyst has been developed to catalyze the asymmetric regioselective [3+2] cycloaddition of 3-isothiocyanato oxindoles with dibenzylidene ketones. A series of spirooxindole enols could be obtained in high yields with good-to-excellent diastereo- and enantioselectivities.