文献类型：期刊文献

英文题名：Rational design of water-dispersible and biocompatible nanoprobes with H2S-triggered NIR emission for cancer cell imaging

作者：Liu, Hengyan[1,2];Xu, Ge[1,2];Zhu, Tianli[1,2];Wang, Rongchen[1,2];Tan, Jiahui[3];Zhao, Chunchang[1,2];Gu, Xianfeng[3]

机构：[1]East China Univ Sci & Technol, Inst Fine Chem, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Shanghai 200237, Peoples R China;[3]Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai 201203, Peoples R China

年份：2020

卷号：8

期号：28

起止页码：6013

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20203609146544);WOS:【SCI-EXPANDED(收录号:WOS:000550975200003)】；

基金：We gratefully acknowledge the financial support from the National Natural Science Foundation of China (21874043, 21672062, and 21977018), the Shanghai Municipal Science and Technology Major Project (Grant No. 2018SHZDZX03) and the Programme of Introducing Talents of Discipline to Universities (B16017).

语种：英文

外文关键词：Biocompatibility - Infrared devices - Diseases - Cells - Cancer cells - Micelles

摘要：We present an approach for constructing a H2S-specific nanoprobe by the entrapment of a small molecule probe within the hydrophobic interior of surface cross-linked micelles (SCMs), endowing the designed nanoprobes with good water solubility and biocompatibility. Importantly, the obtained nanoprobes displayed good responsiveness to H2S in both ratiometric fluorescence and light-up NIR emission modes, thus enabling accurate identification of H2S-rich colorectal cancer cells.