文献类型：期刊文献

英文题名：Reaction-Based SERS Probes for the Detection of Raman-Inactive Species

作者：Chen, Hua-Ying[1,2];Xi, Cheng-Ye[2];Xu, Han-Bin[2];Ye, Ming-Jie[2];He, Yue[2];Chen, Bin-Bin[2];Li, Da-Wei[2]

机构：[1]Zhejiang Shuren Univ, Coll Biol & Environm Engn, Hangzhou 310015, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai Key Lab Funct Mat Chem, Sch Chem & Mol Engn,Key Lab Adv Mat, Shanghai 200237, Peoples R China

年份：2024

卷号：16

期号：49

起止页码：67134

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20244817447123);WOS:【SCI-EXPANDED(收录号:WOS:001366406900001)】；

基金：This work was financially supported by the National Natural Science Foundation of China (grant no. 22176058), the Science and Technology Commission of Shanghai Municipality (grant nos. 22ZR1416800 and 23ZR1416100), the Program of Introducing Talents of Discipline to Universities (B16017), the Fundamental Research Funds for the Central Universities (222201717003), and the Talent Introduction Project of Zhejiang Shuren University (2023R070).

语种：英文

外文关键词：SERS; Chemical reactions; Probe design; Raman-inactive species; A review

摘要：Surface-enhanced Raman spectroscopy (SERS) has the advantages of high sensitivity, low water interference, narrow spectral peaks for multicomponent analysis, and rich molecular fingerprint information, presenting great potential to be a robust analytical technology. However, a key issue is the unavailability in directly detecting Raman-inactive species with a small Raman scattering cross-section. Current research has addressed this issue by using specific chemical reactions to induce significant characteristic changes in SERS signals, enabling the sensitive and selective detection of Raman-inactive species. This reaction-activated SERS sensing strategy provides a clever approach to the precise determination of Raman-inactive species. In this review, we have first summarized the design principles and types of reaction-based SERS probes. Furthermore, we have examined the enormous potential of reaction-based SERS probes in the detection of bioactive species, environmental pollutants, and food contaminants. Finally, we have discussed in depth the challenges and prospects of reaction-based SERS probes on stability, reliability, and intelligence. The review is aimed to inspire a more advanced design of reaction-based SERS probes, thus further facilitating their extensive applications in SERS analysis.