文献类型：专利

英文题名：Use of LTA2 peptide segment, as an intracellular drug transport carrier or to prepare intracellular drug transport carrier, preferably anti-cancer, anti-breast cancer and anti-colon cancer drug carrier

作者：LIU D;MA X;WANG T;WANG P;ZHANG N;ZHENG W

机构：[1]UNIV EAST CHINA SCI & TECHNOLOGY

申请号：CN104491870-A

申请日：2014-12-17

公开日：2015-04-08

语种：英文

收录：DERWENT

摘要：NOVELTY - Use of LTA2 peptide segment, comprising fully defined 44 amino acid residues (SEQ ID NO: 1), as given in the specification, as an intracellular drug transport carrier, is claimed. USE - The LTA2 peptide is useful for preparing intracellular drug transport carrier, preferably anti-cancer, anti-breast cancer and anti-colon cancer drug (claimed). ADVANTAGE - The LTA2 peptide segment: has high transmembrane efficiency; has low number of cationic amino acids; is safe; does not cause cell toxicity; and provides a basis to research TAT, MPG recombination protein with different N-terminal and C-terminal peptides. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for preparation of fusion protein-drug, comprising LTA2 peptide segment linked to a traditional Chinese medicine through a peptide Linker.