文献类型：期刊文献

英文题名：Functional DNA Structures and Their Biomedical Applications

作者：Li, Ziyuan[1,2];Wang, Chen[3];Li, Jiang[4,5];Zhang, Junji[1,2];Fan, Chunhai[5];Willner, Itamar[3];Tian, He[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Joint Int Res Lab Precis Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]Hebrew Univ Jerusalem, Minerva Ctr Biohybrid Complex Syst, Inst Chem, IL-91904 Jerusalem, Israel;[4]Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai 201210, Peoples R China;[5]Shanghai Jiao Tong Univ, Frontiers Sci Ctr Transformat Mol, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China

年份：2020

卷号：2

期号：5

起止页码：707

外文期刊名：CCS CHEMISTRY

收录：WOS:【ESCI(收录号:WOS:000794134700009)】；

基金：The authors thank the NSFC (21788102 and 21878086), Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), the international cooperation program of Shanghai Science and Technology Committee (17520750100), and the Shanghai Rising-Star Program (19QA1402500 to J.Z.).

语种：英文

外文关键词：nucleic acid; nanomaterial/DNA hybrid; DNA nanostructures; DNA logic; cell regulation

摘要：Since the discovery of the double-helix structure in 1953, nucleic acids have been developed from natural genetic codes into functional building blocks in a wide range of biotechnology and materials sciences. Taking advantage of their design diversity and biocompatibility, functional nucleic acids facilitate the "bottom-up" fabrication of nanomaterials that are highly potential for molecular medicine to treat different diseases, such as cancers. The present perspective article introduces recent advances in the use of these unique properties of nucleic acid biopolymers for biomedical applications. Specifically, nano-material/nucleic acid hybrid structures for sensing, controlled drug release, programmable intracellular imaging, and apoptosis, as well as logic calculation, are discussed. Furthermore, the detailed operation for both extracellular and intracellular bioactivity regulation with these new design functional nucleic acid nanostructures are fully illustrated.