文献类型：期刊文献

英文题名：Redox Active Polyphenol Nanoparticles Deprive Endogenous GSH of Electrons for ROS Generation and Tumor Chemodynamic Therapy

作者：Wang, Yifei[1]; Wang, Jia[3]; Chen, Kangli[1]; Jiao, Yunke[1]; Chen, Tianhao[1]; Wu, Xinping[3]; Jiang, Xingwu[2]; Bu, Wenbo[2]; Liu, Changsheng[1]; Qu, Xue[1,4,5]

机构：[1] Key Laboratory for Ultrafine Materials of Ministry of Education, School of Material Science and Engineering, Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai, 200237, China; [2] Department of Materials Science, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, China; [3] Key Laboratory for Advanced Materials, Joint International Research Laboratory for Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Centre for Computational Chemistry, Research Institute of Industrial Catalysis, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China; [4] Wenzhou Institute of Shanghai University, Wenzhou, 325000, China; [5] Shanghai Frontier Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai, 200237, China

年份：2023

外文期刊名：SSRN

收录：EI(收录号：20230143112)

语种：英文

外文关键词：Amines - Drug delivery - Electrons - Nanoparticles - Nanostructured materials - Nitrogen oxides - Quinone - Redox reactions - Tumors

摘要：Chemodynamic therapy (CDT) based on the generation of reactive oxygen species (ROS) is promising for cancer treatment. However, the intrinsic H2O2 is deficient for CDT, and GSH eliminates ROS to protect tumor cells from ROS cytotoxicity. Herein, we propose a strategy to switch the electrons flow direction of GSH for O2 reduction and ROS generation rather than ROS clearance, by using P(DA-Fc) nanoparticles which are polymerized from ferrocenecarboxylic acid (Fc) coupled dopamine. Mechanismly, P(DA-Fc) NPs with phenol-quinone conversion ability mimic NOX enzyme to deprive electrons from GSH to reduce O2 for H2O2 generation, the following ?OH release can be triggered by Fc. Semiquinone radicals in P(DA-Fc) are significantly enhanced after GSH triggering, which are further demonstrated with strong single-electron reduction ability by calculation. In vitro and in vivo experiments demonstrate that P(DA-Fc) can consume intrinsic GSH to produce endogenous ROS, in which the ROS generation performs a strong dependence on GSH/pH level, and eventually cause tumor cells death. Our work makes the first attempt to reverse the function of GSH from ROS scavenger to ROS producer, explores new functions of PDA-based nanomaterials in CDT beyond photothermal reagents and drug carriers, provides a new strategy to improve CDT efficiency. ? 2023, The Authors. All rights reserved.