文献类型：期刊文献

英文题名：Manganese-Loaded Dual-Mesoporous Silica Spheres for Efficient T1- and T2-Weighted Dual Mode Magnetic Resonance Imaging

作者：Niu, Dechao[1];Luo, Xiaofeng[1];Li, Yongsheng[1];Liu, Xiaohang[2];Wang, Xia[3];Shi, Jianlin[1,3]

机构：[1]E China Univ Sci & Technol, Lab Low Dimens Mat Chem, Key Lab Ultrafine Mat, Minist Educ,Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[2]Fudan Univ, Shanghai Canc Hosp, Dept Radiol, Shanghai 200032, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

年份：2013

卷号：5

期号：20

起止页码：9942

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20134516949364);WOS:【SCI-EXPANDED(收录号:WOS:000326212900013)】；

基金：This work was financially supported by the National Basic Research Program of China (973 Program, 2012CB933602); Program for New Century Excellent Talents in University (NCET-10-0379); Scientific Innovation Project of Shanghai Municipal Education Commission (Grant No. 11ZZ53); The National Natural Science Foundation of China (Grant Nos. 51172070, 51132009, and 51202068), and The Fundamental Research Funds for the Central Universities (Grant Nos. WD1114002 and WD1214010).

语种：英文

外文关键词：manganese; dual-mesoporous; dual-mode; magnetic resonance imaging

摘要：A novel class of manganese-based dual-mode contrast agents (DMCAs) based on the core-shell structured manganese-loaded dual-mesoporous silica spheres (Mn-DMSSs) for simultaneous T1- and T2-weighted magnetic resonance imaging (MRI) has been successfully reported. The in vitro MR tests demonstrate that the Mn-based DMCAs display an excellent simultaneous T1-weighted and T2-weighted MR imaging effect with a noticeably high T1 relaxivity (r(1)) of 10.1 mM(-1)s(-1) and a moderately high T2 relaxivity (r(2)) of 169.7 mM(-1)s-(1). The Mn-based DMCAs exhibit negligible cytotoxicity with >80% cell viability at a concentration of up to 200 mu g/mL in human liver carcinoma (HepG2) and mouse macrophage (RAW264.7) cells after 24 Confocal laser scanning microscopy (CLSM) results show that the Mn-DMSSs were internalized via endocytosis and located in the cytoplasm but not in the nucleus. The in vivo experiment shows that the signals of rat liver increased by 29% under T1-weighted imaging mode and decreased by 28% under T2-weighted imaging mode in 5 mm postinjection of Mn-DMSSs, which reveal that the novel Mn-loaded DMSSs can be used as both positive (T1-weighted) and negative (T2-weighted) MR contrast agents in further biomedical applications.