文献类型：期刊文献

英文题名：Efficient Co(OAc)2-catalyzed aerobic oxidation of EWG-substituted 4-cresols to access 4-hydroxybenzaldehydes

作者：Jiang, Jian-An[1];Du, Jia-Lei[1];Liao, Dao-Hua[1];Wang, Zhan-Guo[2];Ji, Ya-Fei[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Roche R&D Ctr China Ltd, Shanghai 201203, Peoples R China

年份：2014

卷号：55

期号：8

起止页码：1406

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000332432300004)，CCR-EXPANDED(收录号:WOS:000332432300004)】；

基金：The authors are grateful to the National Natural Science Foundation of China (No. 21176074) for financial support.

语种：英文

外文关键词：Aerobic oxidation; 4-Cresols; 4-Hydroxybenzaldehydes; Co(OAc)(2); Ethylene glycol

摘要：We reported an efficient ligand-free Co(OAc)(2 center dot)4H(2)O/NaOH/O-2/ethylene glycol reaction system that enables selective aerobic oxidation of a wide range of substrates covering 2,6-di-EWG-, 2,3,6-tri-EWG-, 2-EWG-, and 2-EWG-6-EDG-substituted 4-cresols into the corresponding 4-hydroxybenzaldehydes. Based on the experimental investigations and well-defined p-benzoquinone methides, a plausible reaction mechanism was proposed. Considering the simplicity of the procedure and importance of the products, the methodology was expected to become a favorable and practical tool in related benzylic C(sp(3))-H functionalization chemistry. (C) 2013 Elsevier Ltd. All rights reserved.