文献类型：期刊文献

英文题名：Fluorescence Imaging of Alzheimer's Disease with a Flat Ensemble Formed between a Quinoline-Malononitrile AIEgen and Thin-Layer Molybdenum Disulfide

作者：Dou, Wei-Tao[1,2];Zhang, Jing-Jing[3,4];Li, Qiang[1,2];Guo, Zhiqian[1,2];Zhu, Weihong[1,2];Chen, Guo-Rong[1,2];Zhang, Hai-Yan[3,4];He, Xiao-Peng[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China;[4]Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China

年份：2019

卷号：20

期号：14

起止页码：1856

外文期刊名：CHEMBIOCHEM

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000477933400017)】；

基金：This research was financially supported by the National Natural Science Foundation of China (21722801, 21572058, and 81522045), the Fundamental Research Funds for the Central Universities (222201717003), the Shanghai Rising-Star Program (16QA1401400), and the National R&D projects for major research instruments (ZDYZ2013-1).

语种：英文

外文关键词：Alzheimer's disease; fluorescence; imaging agents; peptides; self-assembly

摘要：The sensitive imaging of amyloid-beta (A beta) peptides is important for the timely detection of neurodegenerative diseases, such as Alzheimer's disease (AD). Although clinically the diagnosis of AD relies on the use of radiolabeled imaging reagents, herein we report the simple construction of a "flat ensemble" formed between a quinoline-malononitrile AIEgen (EDS) and thin-layer molybdenum disulfide (2D MoS2) for the sensitive detection of A beta by means of fluorescence-based techniques. Self-assembly between EDS and 2D MoS2 in aqueous buffer solution produces the flat ensemble, and the subsequent interaction of the material ensemble with oligomeric and aggregated A beta peptides leads to up to 19-fold enhanced fluorescence of EDS. The ensemble is also applicable for staining A beta aggregates in vivo.