文献类型：期刊文献

中文题名：部分析因设计法优化分散聚合制备单分散种子微球

英文题名：OPTIMIZATION OF PREPARATION OF MONODISPERSE SEEDS BY DISPERSION POLYMERIZATION USING FRACTIONAL FACTORIAL DESIGN

作者：于英豪[1];刘坐镇[2];徐环昕[2];邬行彦[1]

机构：[1]华东理工大学生物反应器工程国家重点实验室,上海200237;[2]上海华震科技有限公司,上海200237

年份：2006

卷号：22

期号：3

起止页码：254

中文期刊名：离子交换与吸附

外文期刊名：Ion Exchange and Adsorption

收录：CSTPCD;;EI(收录号：20063110034433);Scopus;北大核心:【北大核心2004】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：灌注色谱;分散聚合;单分散;正丁醇;析因设计

外文关键词：Perfusion chromatography; Dispersion polymerization; Monodisperse; n-Butanol; Factorial design

摘要：采用分散聚合法,以正丁醇为分散介质、苯乙烯为单体、聚乙烯吡咯烷酮(PVP)为分散剂、偶氮二异丁腈(AIBN)为引发剂,制备单分散聚苯乙烯微球作为色谱填料的种子。实验以微球的平均粒径为主要考察指标,以GSD为次要考察指标,通过部分析因设计,获得了粒径为10μm的单分散(GSD=1.06)微球。
Monodisperse polystyrene microspheres as the seeds for making perfusion chromatography packing materials were prepared by dispersion polymerization in n-butanol reaction media using polyvinylpyrrolidone （PVP） as a stabilizer and 2, 2＇-azobisizobutyronitrile （AIBN） as an initiator. Fractional factorial designs were carried out with the mean size of polystyrene mierospheres as the main judging criterion and geometric standard deviation （GSD） as an additional one, obtaining an optimal monodisperse （GSD=1.06） polystyrene mierospheres with the size of 10μm.