文献类型：期刊文献

英文题名：Chiral phosphine-squaramide-catalyzed Morita-Baylis-Hillman reaction: enantioselective synthesis of 3-hydroxy-2-oxindoles

作者：Qian, Jing-Ying[1,2];Wang, Ci-Ci[1,2];Sha, Feng[1,2];Wu, Xin-Yan[1,2,3]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

年份：2012

卷号：2

期号：14

起止页码：6042

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20122715198747);WOS:【SCI-EXPANDED(收录号:WOS:000305693700026)】；

基金：We are grateful for the financial support from National Natural Science Foundation of China (20772029), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Rate constants - Phosphorus compounds

摘要：Phosphine-squaramide derivatives were developed to catalyze the enantioselective Morita-Baylis-Hillman reaction of acrylates with isatins to construct 3-hydroxy-2-oxindoles with quaternary stereocenters. In the presence of 2 mol% H-bonding catalyst 3e, the desired products were achieved in high yields and good-to-excellent enantioselectivities (up to 95% ee).