文献类型：期刊文献

英文题名：Supramolecular-based PEGylated magnetic hybrid vesicles with ultra-high transverse relaxivity

作者：He, Jianping[1];Liu, Xiaohang[2];Niu, Dechao[1];Chen, Jianzhuang[1];Qin, Xing[1];Li, Yongsheng[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Lab Low Dimens Mat Chem,Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Fudan Univ, Shanghai Canc Hosp, Dept Radiol, Shanghai 200032, Peoples R China

年份：2018

卷号：11

起止页码：238

外文期刊名：APPLIED MATERIALS TODAY

收录：;EI(收录号：20184906208717);WOS:【SCI-EXPANDED(收录号:WOS:000432609800018)】；

基金：This work was financially supported by the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002); the National Key Research and Development Program of China (Grant No. 2016YFA0203700); NSFC (Grant Nos. 51461165202, 51472085 and 51572083); the Program of Shanghai Academic Research Leader (18XD1401400); the Shanghai Rising Star Program (16QA1401300); the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning; the 111 project (B14018); the Basic Research Program of Shanghai (17JC1404702) and the Fundamental Research Funds for Central Universities (222201718002).

语种：英文

外文关键词：Supramolecular; Magnetic hybrid vesicles; Colloidal stability; Transverse relaxivity

摘要：Magnetic vesicles have attracted great attention due to their excellent magnetic properties and wide potentials for application in magnetic resonance imaging. In the present study, we designed and synthesized a new kind of supramolecular-based PEGylated magnetic hybrid vesicles (SPMHVs) that works as a T-2-weighted MR contrast agent with ultra-high transverse relaxivity up to 641.7 mM(-1) s(-1). The construction of SPMHVs was achieved by self-assembly of the newly synthesized supramolecular-based amphiphilic pseudo-block copolymer polyrotaxane-poly (acrylic acid; PR-PAA) and hydrophobic magnetite nanoparticles, followed by cross-linking with organosilica of 3-mercaptopropyltrimethoxysilane (MPTMS) and poly (ethylene glycol; PEG) modification. Interestingly, the morphology of SPMHVs can be tuned between vesicles and micelles by changing the initial Fe3O4 concentrations in the oil phase (or the Fe3O4 loading amount). A sample of SPMHVs-30 nanoparticles obtained with initial magnetite concentration of 3.0 mg/ml in the oil phase especially displayed well-defined vesicular morphology, relatively small particle sizes (<100 nm) and excellent colloidal stability under biological conditions. More importantly, the in vivo MR imaging testing results demonstrate that the SPMHVs-30 displayed significantly enhanced T2-weighted contrast imaging performance with passive targeting behavior via permeability and retention (EPR) effects, further demonstrating the promising MR imaging potential of these agents. (C) 2018 Elsevier Ltd. All rights reserved.