文献类型：专利

英文题名：New benzodiazepine derivative used for treating colon cancer, breast cancer, lung cancer and cervical cancer

作者：XU X;LI W;LI Z;LIU J;CHEN Y

机构：[1]UNIV EAST CHINA SCI & TECHNOLOGY

申请号：CN103435562-A

申请日：2013-08-26

公开日：2013-12-11

语种：英文

收录：DERWENT

摘要：NOVELTY - Benzodiazepine derivative (I) is new. USE - Benzodiazepine derivative used for treating colon cancer, breast cancer, lung cancer and cervical cancer (claimed). DETAILED DESCRIPTION - Benzodiazepine derivative of formula (I) is new. X=O, S or -NH; Y'=alkyl or haloalkyl; A=1-6C alkyl, 1-6C alkoxy, 2-6C alkenyl, 2-6C alkynyl, phenyl, benzyl, naphthyl, nitrogen, oxygen, sulfur, 5-6C heteroaryl, 5-6C heterocyclic or 8-12C bicyclic heteroaryl optionally substituted with halogen, cyano, trifluoromethyl, trifluoroacetyl, trifluoromethanesulfonyl, R1, OR1, NR1R2, C(O)R1, C(O)OR1, C(O)NR1R2, SR1, S(O)mR1, S(O)2NR1R2, OC(O)R1, OC(O)NR1R2, OS(O)2R1, OS(O)2NR1R2, N(R2)C(O)R1, N(R2)C(O)NR1R2, N(R2)S(O) or N(R2)S(O)2NR1R2; R1,R2=H, 1-6C alkyl, 1-6C alkoxy, 1-6C haloalkyl, 2-6C alkenyl, 2-6C haloalkenyl, 2-6C haloalkyl, 3-7C cycloalkyl, 5-7C cycloalkenyl, phenyl or 5-6C heterocyclic optionally substituted with halogen, cyano, trifluoromethyl, trifluoroacetyl, trifluoromethanesulfonyl, 1-6C alkyl, 1-6C alkoxy, 1-6C haloalkyl, 2-6C alkenyl, 2-6C haloalkenyl, 2-6C alkynyl, 2-6C haloalkynyl, hydroxy, hydroxyalkyl, 1-4C alkyl, OR3, NR3R4, C(O)R3, C(O)OR3, C(O)NR3R4, SR3, S(O)mR3, S(O)2NR3R4, OC(O)R3, OC(O)NR3R4, OS(O)2R3, OS(O)2NR3R4, N(R3)C(O)R4, N(R3)C(O)NR4R5, N(R3)S(O)2R4 or N(R3)S(O)2NR4R5; R3,R4,R5=H, 1-6C alkyl, 1-6C alkoxy, 1-6C haloalkyl, 2-6C alkenyl, 2-6C haloalkenyl, 2-6C alkynyl or 2-6C haloalkynyl; B'=1-6C alkoxy or 2-6C alkenyl optionally substituted with 1-6C alkyl, 1-6C alkoxy, 2-6C alkenyl, 2-6C alkynyl or phenyl optionally substituted with halogen, cyano, nitro, trifluoromethyl, acetyl, trifluoromethanesulfonyl, R7, OR7, SR7, NR1R8N(O)R7, C(O)OR7, S(O)mR7, S(O)2NR7R8, OC(O)R7, OS(O)2R7, OS(O)2NR7R8 or N(R7)S(O)2R7; R7,R8=H, 1-6C alkyl, 1-6C alkoxy, 1-6C haloalkyl, 2-6C alkenyl, 2-6C haloalkenyl, 2-6C haloalkyl, 3-7C cycloalkyl, 5-7C cycloalkenyl or phenyl optionally substituted with halogen, cyano, nitro, trifluoromethyl, trifluoroacetyl, trifluoromethanesulfonyl, OR3, SR3, NR3R4, C(O)R3, C(O)OR3, S(O)mR3, S(O)2NR3R4, OC(O)R3, OS(O)2R3, OS(O)2NR3R4 or N(R4)S(O)2R3; and m=1-2.