文献类型：期刊文献

英文题名：Transition-Metal-Free Sonogashira-Type Cross-Coupling of Alkynes with Fluoroarenes

作者：Jin, Guanyi[1];Zhang, Xuxue[1];Cao, Song[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

年份：2013

卷号：15

期号：12

起止页码：3114

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000320979000057)，CCR-EXPANDED(收录号:WOS:000320979000057)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (Nos. 21072057, 21272070), the Twelfth Five-year Plan of China (2011BAE06B01-15), and the 973 Program (2010CB126101).

语种：英文

摘要：A novel, inexpensive, and efficient palladium-, copper-, ligand-, and amine-free Sonogashira-type cross-coupling reaction of terminal alkynes with unreactive aryl fluorides in the presence of sodium, sodium methoxide, and calcium hydroxide under the assistance of a Grignard reagent was developed. A plausible mechanism was also suggested.