文献类型：期刊文献

英文题名：Palladium-Catalyzed Regioselective Domino Spirocyclization of Carbamoyl Chlorides with Alkynes and Benzynes

作者：Wang, Chenchen[1,2];Zhao, Wenyu[1,2];Wu, Xianqing[1,2];Qu, Jingping[1,2];Chen, Yifeng[1,2]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Mat & Dynam Chem, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat,Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Mat & Dynam Chem, Feringa Nobel Prize Scientist Joint Res Ctr, Joint Int Res Lab Precis Chem & Mol Engn,Sch Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2020

卷号：362

期号：22

起止页码：4996

外文期刊名：ADVANCED SYNTHESIS & CATALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000572174900001)，CCR-EXPANDED(收录号:WOS:000572174900001)】；

基金：This work was supported by NSFC/China (21421004, 21702060), Shanghai Rising-Star Program, Shanghai Municipal Science and Technology Major Project (Grant No.2018SHZDZX03) and the Program of Introducing Talents of Discipline to Universities (B16017), and the Fundamental Research Funds for the Central Universities. Y.C. thank Prof. Feng Sha (ECUST) for generous donation of benzyne precursors for product 5 b and 5 c. The authors thank Research Center of Analysis and Test of East China University of Science and Technology for the help on NMR analysis.

语种：英文

外文关键词：Palladium; Domino reaction; Spirooxindoles; Carbamoyl chlorides; C-H activation

摘要：A palladium-catalyzed domino spiro-cyclization of carbamoyl chlorides with alkynes and benzynes, involving intramolecular C-H activation to afford valuable oxindole scaffolds bearing spiro quaternary stereocenters, has been developed. This one-step synthesis of spirooxindole is both step- and atom-economic, proceeding with high regioselectivity in moderate to excellent yields.