文献类型：期刊文献

英文题名：ROS-Responsive Selenium-Containing Carriers for Coencapsulation of Photosensitizer and Hypoxia-Activated Prodrug and Their Cellular Behaviors

作者：Song, Fangqin[1];Li, Siqi[1];Sun, Chuanhao[1];Ji, Ying[3];Zhang, Yan[1,2]

机构：[1]East China Univ Sci & Technol, Sch Mat & Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China;[3]Hong Kong Polytech Univ, Inst Text & Clothing, Hunghom, Kowloon, Hong Kong 999077, Peoples R China

年份：2021

卷号：21

期号：12

外文期刊名：MACROMOLECULAR BIOSCIENCE

收录：;EI(收录号：20213310767434);WOS:【SCI-EXPANDED(收录号:WOS:000684452600001)】；

基金：This work was supported by the National Natural Science Foundation of China (52073093, 51873062), School of Pharmacy, Fudan University & the Open Project Program of Key Lab of Smart Drug Delivery (Fudan University, SDD2019-02). The authors thank Pengfei Sun (Institute of Advanced Materials, Nanjing University of Posts & Telecommunications, Nanjing 210023, China) for sharing their equipment to execute the experiments in vitro.

语种：英文

外文关键词：hypoxia-activated prodrugs; photodynamic therapy; polycarbonates; ROS responsive; selenium

摘要：The integration of hypoxia-activated chemotherapy with photodynamic therapy (PDT) has newly become a potent strategy for tumor treatment. Herein, a reactive oxygen species (ROS)-responsive drug carriers (PS@AQ4N/mPEG-b-PSe NPs) are fabricated based on the amphiphilic selenium-containing methoxy poly(ethylene glycol)-polycarbonate (mPEG-b-PSe), the hydrophobic photosensitizer (PS), and hypoxia-activated prodrug Banoxantrone (AQ4N). The obtained nanoparticles are spherical with an average diameter of 100 nm as characterized by transmission electron microscope (TEM) and dynamic laser scattering (DLS) respectively. The encapsulation efficiency of the PS and AQ4N reaches 92.83% and 51.04% at different conditions, respectively, by UV-vis spectrophotometer. It is found that the drug release is accelerated due to the good ROS responsiveness of mPEG-b-PSe and the cumulative release of AQ4N is up to 89% within 30 h. The cell test demonstrates that the nanoparticles dissociate when triggered by the ROS stimuli in the cancer cells, thus the PS is exposed to more oxygen and the ROS generation efficiency is enhanced accordingly. The consumption of oxygen during PDT leads to the increased tumor hypoxia, and subsequently activates AQ4N into cytotoxic counterpart to inhibit tumor growth. Therefore, the synergistic therapeutic efficacy demonstrates this drug delivery has great potential for antitumor therapy.