文献类型：期刊文献

英文题名：pH/near-infrared light dual activated Ce6-doped silicon nanoparticles with tumor chemo-photodynamic synergistic therapy for improving efficiency of monotherapy

作者：Ma, Tonghao[1];Zhang, Qi[1];Xuan, Qize[1];Zhuang, Jiafeng[1];Zhang, Wei[1];Li, Hui[2];Chen, Chao[1];Wang, Ping[1,3]

机构：[1]East China Univ Sci & Technol, Biomed Nanotechnol Ctr, Shanghai Collaborat Innovat Ctr Biomfg, State Key Lab Bioreactor Engn,Sch Biotechnol, Shanghai 200237, Peoples R China;[2]Shanghai Univ, Sch Environm & Chem Engn, Inst Environm Pollut & Hlth, Shanghai 200444, Peoples R China;[3]Univ Minnesota, Dept Bioprod & Biosyst Engn, St Paul, MN 55108 USA

年份：2021

卷号：424

外文期刊名：CHEMICAL ENGINEERING JOURNAL

收录：;EI(收录号：20212310454656);WOS:【SCI-EXPANDED(收录号:WOS:000707037200101)】；

基金：This work was sponsored by the National Natural Science Founda-tion of China (Nos. 21908059, 41907318 and 21636003) , the China Postdoctoral Science Foundation (No. 2019M651419) , Shanghai Sailing Program (No. 19YF1410900) , the Fundamental Research Funds for the Central Universities (No. 22221818014) , the Shanghai Post-doctoral Excellence Program (No. 2018011) , the Open Funding Project of the State Key Laboratory of Bioreactor Engineering, and the Project Sup-ported by the Foundation (No. GZKF202031) of State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Tech-nology, Shandong Academy of Sciences.; All animal experiments were conducted in accordance with Chinese legislation on the Use and Care of Research Animals (Document No. 55, 2001) , and institutional guidelines for the Care and Use of Laboratory Animals established by the East China University of Science and Tech-nology Animal Studies Committee, and this committee approved the experiments.

语种：英文

外文关键词：Drug delivery; Ce6-doped nanoparticle; Dual response; Tumor targeting; Chemo-photodynamic synergistic therapy

摘要：Currently, single chemotherapeutics or photosensitizers implemented in clinic present huge challenges in terms of unfavorable therapeutic efficacy, physiological instability and non-selective toxicity. In order to remedy the faultiness of insufficient efficiency of monotherapy, we herein synthesized an "all-in-one" targeting drug delivery system with multimodal therapy based on chemo-photodynamic synergistic therapy. Specifically, mesoporous silica nanorods were first synthesized through doping chlorin e6 (Ce6) in the sol-gel process, and then were used to load chemotherapy drug. After the amino groups and boronic acid groups were sequentially modified on the surface of nanoparticles, lactobionic acid (LA) was chosen as an intermediary to achieve simultaneous crosslinking of targeting agent LA and sealing agent sericin through pH responsive boronic ester linkage. The obtained ultimate nanocomposites possessed good biocompatibility, colloidal stability and hemocompatibility. Besides, in vitro endocytosis experiment performed with confocal laser scanning microscopy and flow cytometry testified the LA-mediated accurate tumor-specific targeting ability of synthesized nanocarriers. Moreover, a series of in vitro assays demonstrated that fabricated therapeutic nanoplatform could not only release loaded drugs in response to acidic environment to achieve chemotherapy, but also could generate singlet oxygen from photosensitizer Ce6 under external light stimulation to realize photodynamic therapy. Most interestingly, the combination therapy including photodynamic therapy and chemotherapy exhibited a synergistic effect against tumor cells in both in vivo and ex vivo experiments. Briefly, the drug delivery system reported here could attain effective chemophotodynamic synergistic therapy to dispose of the insufficient lethality of monotherapy while guaranteeing the safety during in vivo application.