文献类型：期刊文献

英文题名：Two-dimensional mesoporous nitrogen-rich carbon nanosheets loaded with CeO2 nanoclusters as nanozymes for the electrochemical detection of superoxide anions in HepG2 cells

作者：Wang, Zhenxing[1];Zhao, Hongli[1];Chen, Kaicha[1];Zhou, Fangfang[1];Magdassi, Shlomo[2];Lan, Minbo[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]Hebrew Univ Jerusalem, Inst Chem, Casali Ctr Appl Chem, IL-91904 Jerusalem, Israel

年份：2022

卷号：209

外文期刊名：BIOSENSORS & BIOELECTRONICS

收录：;EI(收录号：20221411917912);WOS:【SCI-EXPANDED(收录号:WOS:000793101400003)】；

基金：Acknowledgments This work was supported by the Science and Technology Commission of Shanghai Municipality (STCSM, 20520712500; 20392002300) .

语种：英文

外文关键词：Two-dimensional; Pore structure; Metal oxides nanoclusters; Nitrogen-rich carbon; Superoxide anions

摘要：Two-dimensional (2D) porous carbon-based composite nanosheets loaded with metal oxide nanoclusters are expected to be promising electrocatalysts for high-performance electrochemical sensors. However, for this complicated composite material, strict reaction conditions and complex synthesis steps limit its general application in electrochemical detection. Here we present a facile method to fabricate 2D mesoporous nitrogen-rich carbon nanosheets loaded with CeO2 nanoclusters (2D-mNC@CeO2), for fabricating superoxide anions (O-2(center dot)) electrochemical sensor. The method is based on block copolymers self-assembly and the affinity of polydopamine to metal ions to obtain organic-inorganic hybrid, which can be directly converted into 2D-mNC@CeO2 through carbonization strategy without structural deterioration. Characterizations demonstrate that the 2D-mNC@CeO2 owned the 2D N-doped carbon structure with an interlinked hierarchical mesoporous and the uniformly dispersed CeO2 nanoclusters on the surface. Benefitted from the unique structure, the 2D-mNC@CeO2 shortens electron transfer distance, enhances mass transfer efficiency, exposes numerous active sites, and obtain a high Ce3+/Ce4+ ratio for improving electrocatalytic performance. The 2D-mNC@CeO2/SPCEs sensors for O-2(center dot) detection has a detection limit of 0.179 mu M (S/N = 3) and sensitivity of 401.4 mu A cm(-2) mM-1. The sensors can be applied to capture electrochemical signals of O-2(center dot) released from HepG(2) cells, demonstrating the application potential of the sensors to monitor O-2(center dot) in biological fields.