文献类型：期刊文献

英文题名：Visualizing Aβ deposits in live young AD model mice with a simple red/near-infrared-fluorescent AIEgen

作者：Wang, Yipu[1];Mei, Dong[2];Zhang, Xinyi[1];Qu, Da-Hui[1];Mei, Ju[1]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat,Joint Int Res Lab Precis Chem & M, Feringa Nobel Prize Scientist Joint Res Ctr,Sch C, Frontiers Sci Ctr Materiobiol & Dynam Chem,Inst F, Shanghai 200237, Peoples R China;[2]Capital Med Univ, Natl Ctr Childrens Hlth, Beijing Childrens Hosp, Clin Res Ctr, Beijing 100045, Peoples R China

年份：2022

卷号：65

期号：2

起止页码：339

外文期刊名：SCIENCE CHINA-CHEMISTRY

收录：;EI(收录号：20214611151889);WOS:【SCI-EXPANDED(收录号:WOS:000716865600003)】；

基金：This work was supported by the National Natural Sciences Foundation of China (21788102, 21875064, 81903545, 21604023, 21790361), Shanghai Science and Technology Commission Basic Project-Shanghai Natural Science Foundation (21ZR1417600), Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), Programme of Introducing Talents of Discipline to Universities (B16017), Shanghai Science and Technology Committee (17520750100), Beijing New-Star Plan of Science and Technology (Z201100006820009), Shanghai Sailing Program (16YF1402200), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：A beta deposits; AIE; Alzheimer's disease (AD); red/NIR fluorescence; in-vivo imaging; diagnosis

摘要：Precise and early detection of beta-amyloid (A beta) deposits in situ and in real time is pivotal to the diagnosis and early intervention of Alzheimer's disease (AD). Optical imaging stands out to be a promising technique for such a task; however, it still remains a big challenge, due to the lack of high-performance imaging contrast agent. Restricted by poor blood-brain barrier (BBB) penetrability, short-wavelength excitation and emission, as well as the aggregation-caused quenching effect, the widely used gold-standard probes cannot be used for early in-vivo imaging of A beta deposits. Herein, we integrate the A beta deposits-favored geometry, amphiphilic and zwitterionic molecular structure, extended D-pi-A electronic structure, and 3D conformation into one molecule, facilely establishing a simple and economic imaging contrast agent that enjoys high specificity and affinity to A beta deposits, good BBB penetrability, bright red/near-infrared fluorescence, low interference from autofluorescence, aggregation-induced emission (AIE) feature, high signal-to-noise ratio (SNR), and high contrast. In-vitro, ex-vivo, and in-vivo experiments with different strains of mice indicate that AIE-CNPy-AD holds the universality to A beta deposits identification. Noteworthily, AIE-CNPy-AD is even able to precisely trace the small and sparsely-distributed A beta deposits in AD model mice as young as 4-month-old APP/PS1 mice, the youngest having A beta deposits. Moreover, the present probe could clearly reveal the increase and enlargement of A beta deposits as the mice grow. Therefore, AIE-CNPy-AD might be an ideal alternative for early AD diagnosis and highly reliable monitoring of AD progression.