文献类型：期刊文献

英文题名：8-Quinolinyl Oxazoline: Ligand Exploration in Enantioselective Ni-Catalyzed Reductive Carbamoyl-Alkylation of Alkene to Access the Chiral Oxindoles

作者：Luan, Baixue; Tang, Zaiquan; Wu, Xianqing; Chen, Yifeng

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Frontiers Sci Ctr Mat & Dynam Chem, Feringa Nobel Prize Sci Joint Res Ctr,Joint Int R, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2022

卷号：33

期号：18

起止页码：1847

外文期刊名：SYNLETT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000826495500002)】；

基金：This work was sponsored by the National Natural Science Foundation of China (22171079), the Natural Science Foundation of Shanghai (21ZR1480400), the Shanghai Rising-Star Program (20QA1402300), the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), the Program of Introducing Talents of Discipline to Universities, Project 211 (B16017), the Fundamental Research Funds for the Central Universities (222201717003), and the China Postdoctoral Science Foundation (2021M701197).

语种：英文

外文关键词：chiral ligand; nickel catalysis; reductive coupling; dicarbo-functionalization of alkene; oxindole

摘要：Chiral ligands play an essential role in transition-metal-catalyzed enantioselective transformations, in which chiral oxazoline-based scaffolds are the privileged chiral ligand. Nevertheless, 8-quinolinyl oxazoline (8-Quinox) ligands are underexplored in transition-metal-catalyzed asymmetric transformations since their development in 1998. Herein, we report an 8-Quinox ligand promoted Ni-catalyzed enantioselective reductive carbamoyl-alkylation of carbamoyl chloride tethered styrene with unactivated alkyl iodide, providing an expedient access to valuable enantioenriched oxindoles in good results.