文献类型：期刊文献

英文题名：Organocatalytic annulation of aldehydes and o-quinone methides: A facile access to dihydrocoumarins

作者：Zhou, Ding[1];Mao, Kaizhe[1];Zhang, Jian[1];Yan, Bingliang[1];Wang, Wei[1,2];Xie, Hexin[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2016

卷号：57

期号：50

起止页码：5649

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000389293100024)，CCR-EXPANDED(收录号:WOS:000389293100024)】；

基金：This work was financially supported by the "Thousand Plan" Youth Program, the Fundamental Research Funds for the Central Universities, and East China University of Science & Technology.

语种：英文

外文关键词：Organocatalysis; o-Quinone methide; Dihydrocoumarin

摘要：A [4+2] annulation of aldehydes and o-quinone methides catalyzed by a secondary amine is developed. This process leads to biologically important dihydrocoumarins in moderate to good yields after oxidation. In addition, the employment of a chiral secondary amine catalyst allows access to optically active dihydrocoumarins with up to 64% ee. (C) 2016 Elsevier Ltd. All rights reserved.