文献类型：期刊文献

英文题名：Synthesis of α,α-difluoro-γ-butyrolactones via ethyl iododifluoroacetate

作者：Xiao, FH; Wu, FH; Shen, YJ; Zhou, LF

机构：[1]E China Univ Sci & Technol, Coll Chem & Pharmaceut, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

年份：2005

卷号：126

期号：1

起止页码：63

外文期刊名：JOURNAL OF FLUORINE CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000226427900009)，CCR-EXPANDED(收录号:WOS:000226427900009)】；

语种：英文

外文关键词：synthesis; alpha,alpha-difluoro-gamma-butyrolactone; ethyl iododifluoroacetate; sodium dithionite

摘要：A novel synthesis of alpha,alpha-difluoro-gamma-butyrolactones was realized by the alkaline hydrolysis of the adducts of ethyl iododifluoroacetate and alkenes. Ethyl iododifluoroacetate reacted with alkenes in the presence of sodium dithionite to give the addition products in 62-78% yields. The products were hydrolyzed in 10% aqueous sodium carbonate solution to give alpha,alpha-difluoro-gamma-butyrolactones in 93-98% yields. (C) 2004 Elsevier B.V. All rights reserved.