文献类型：期刊文献

中文题名：粒径对甘草粉末中甘草酸、甘草苷的影响

英文题名：Effect of particle size on glycyrrhizic acid and liquiritin of Glycyrrhizae Radix et Rhizoma powder

作者：张立国[1];闫志慧[1];陈露[1];倪力军[1]

机构：[1]华东理工大学化学与分子工程学院,上海200237

年份：2013

卷号：44

期号：23

起止页码：3328

中文期刊名：中草药

外文期刊名：Chinese Traditional and Herbal Drugs

收录：CSTPCD;;Scopus;北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；

基金：上海市科学技术委员会支撑计划项目(13401901100)

语种：中文

中文关键词：甘草;甘草酸;甘草苷;粒径;体外释放

外文关键词：Glycyrrhizae Radix et Rhizoma; glycyrrhiza acid; liquiritin; particle size; HPLC; in vitro release

摘要：目的研究粒径对常用中药甘草粉末中活性成分(甘草酸、甘草苷)的质量分数及其体外溶出性能的影响,为甘草粉末的制备提供适宜的粒径范围。方法将甘草粉碎、过筛制成7种不同粒径规格的样品并进行其粒度测试和扫描电镜分析,采用TCL法对样品进行定性鉴别;采用HPLC法分析样品中甘草酸、甘草苷的量及其体外溶出性能。结果样品中甘草苷和甘草酸的量随粒径减小而增大。2种成分的量在300～900μm、105～300μm及小于105μm这3种粒径间波动比较平稳,且粒径105～150μm样品有效成分有良好的体外释放度。结论在甘草粉末制备过程中,将粒径控制在105～150μm,可使样品中活性成分甘草酸、甘草苷的量较高、稳定并有良好的体外释放性能。
Objective To study the effect of particle size on the contents and in vitro dissolution performances of the active ingredients （glycyrrhizic acid and liquiritin） in Glycyrrhizae Radix et Rhizoma powder, for the purpose of providing the appropriate particle size during the preparation of Glycyrrhizae Radix et Rhizoma powder. Methods Seven Glycyrrhizae Radix et Rhizoma powder samples with different particle sizes were prepared in present work. Their micro-topography structures were characterized by particle size distribution and scanning electron microscopy （SEM）. Thin-layer chromatography （TLC） was applied to qualitatively identify these samples. The contents and in vitro release performance of glycyrrhizic acid and liquiritin in the seven powder samples were analyzed by high performance liquid chromatography （HPLC）. Results The contents of glycyrrhizic acid and liquiritin increased with the decrease of particle sizes of the Glycyrrhizae Radix et Rhizoma powder samples. When the powder sizes were in the range of 300--900 ~tm, 105--300 ~tm or less than 105 I.tm, the contents of liquiritin and glycyrrhizic acid were stable. And 105-- 150 ~tm sample had good release performance in vitro. Conclusion Controlling the particle size between 105 and 150 ktm during the granulation process of preparing Glycyrrhizae Radix et Rhizoma powder would make the contents of liquiritin and glycyrrhizic acid in Glycyrrhizae Radix et Rhizoma powder hi^her, stable and have ~ond in vitro ro｜~a^o n~＇rleNrr^nnot~