文献类型：期刊文献

英文题名：A new turn-on fluorescent chemosensor based on diketopyrrolopyrrole (DPP) for imaging Zn2+ in living cells

作者：Zhang, Guanjun[1,2];Li, Haiying[3,4];Bi, Shiming[1,2];Song, Longfeng[1,2];Lu, Yunxiang[3,4];Zhang, Liang[1,2];Yu, Jianjun[1,2];Wang, Limin[1,2]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[4]E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China

年份：2013

卷号：138

期号：20

起止页码：6163

外文期刊名：ANALYST

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000324545000038)】；

基金：This research was financially supported by the National Nature Science Foundation of China (21272069, 20672035), the Fundamental Research Funds for the Central Universities, Baihehua Group and Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.

语种：英文

摘要：A new turn-on fluorescent chemosensor, DPPL1, was rationally designed and synthesized based on diketopyrrolopyrrole (DPP), which presented high sensitivity and selectivity for Zn2+. Specifically, DPPL1 presented a large emission enhancement and a 70 nm blue-shift upon Zn2+ binding. H-1 NMR titrations, studies into the pH effects and DFT calculations further proved that this phenomenon was due to both photo-induced electron transfer (PET) and intra-molecular charge transfer (ICT) processes. More importantly, DPPL1 was successfully used for imaging Zn2+ in living HeLa cells. To the best of our knowledge, this is the first DPP-based fluorescent chemosensor to recognize Zn2+ ions in living cells with a large blue-shift and a fluorescent enhancement based on both photo-induced electron-transfer (PET) and intramolecular charge-transfer (ICT) effects. Meanwhile, we have also provided a new effective platform for the development of fluorescent chemosensors for other analytes.