文献类型：期刊文献

英文题名：Comparative cytotoxic effects of five commonly used triazole alcohol fungicides on human cells of different tissue types

作者：Xu, Jiuyong[1];Xiong, Hui[1];Zhang, Xianfei[1];Muhayimana, Solange[1];Liu, Xuefeng[1];Xue, Yufan[1];Huang, Qingchun[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2020

卷号：55

期号：5

起止页码：438

外文期刊名：JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES

收录：;EI(收录号：20201508394444);WOS:【SCI-EXPANDED(收录号:WOS:000520553900001)】；

基金：This work was financially supported by the key scientific and technological project supported by Science and Technology Committee of Shanghai Municipality, China (No. 19391902400).

语种：英文

外文关键词：Triazole alcohol fungicides; cytotoxicity; human cells; ROS generation; apoptosis

摘要：The widespread application of triazole fungicides makes people attach great concern over its adverse effects in mammalian. In this paper, cytotoxic effects of triazole alcohol fungicides (TAFs) were assessed on human HeLa, A549, HCT116 and K562 cells, and the potential mechanism of TAFs cytotoxicity was studied preliminarily. Results showed that TAFs had cytotoxicity on human cells with different level and cytotoxic selectivity. TAFs cytotoxicity was resonated with a typical hormetic biphasic dose action that produced a complex pattern of stimulatory or inhibitory effects on cell viability. Among the five TAFs, diniconazole revealed a widest range of cytotoxicity to inhibit the viability of the adherent and the suspension cells, causing HeLa cells shrinkage, A549 cells shrunken, and K562 cells collapse, and showed stronger cytotoxicity than hexaconazole. Moreover, the involvement of ROS generation in the cytotoxicity of TAFs on human cells was observed, and the apoptosis of HeLa cells and the formation of apoptotic body in K562 cells induced by diniconazole were characterized. The results indicated the cytotoxicity of TAFs with different structures on human cells was depended on their own property and cell specificity, K562 cells were the most susceptible to TAFs and diniconazole was the strongest toxic.