文献类型：期刊文献

英文题名：Mussel-InspiredDopamine-Cu(Ii)Coated Polyetheretherketone Surface with Direct and Immunomodulatory Effect to Enhance Osteogenesis, Angiogenesis, and Antibacterial Ability

作者：Lyu, Zhuocheng[1]; Zhao, Yaochao[1]; Huo, Shicheng[1]; Wang, Fan[2]; Meng, Xiangchao[1]; Yuan, Zhiguo[1]; Long, Teng[1]; Wang, You[1]

机构：[1] Department of Bone and Joint Surgery, Department of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China; [2] Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China

年份：2022

外文期刊名：SSRN

收录：EI(收录号：20220147235)

语种：英文

外文关键词：Amines - Copper compounds

摘要：Implant-associated infection (IAI) and insufficient implant osseointegration are two primary concerns of implant failure. Polyetheretherketone (PEEK), though widely used in orthopedic implants, has been limited in clinical applications by its poor osteogenic activity, inferior antibacterial ability, and improper immunological reactions. In this study, copper (Cu), a multi-functional bioactive ion, was incorporated into the polydopamine (PDA) coating on PEEK surfaces using a metal-catecholamine assembling strategy. This DA-Cu II coating induced a spatial distribution of Cu, exerting biological functions simultaneously through passive contact and active release of Cu. DA-Cu II coated PEEK surfaces exhibited not only superior abilities of osteogenesis, angiogenesis, and antibiosis but also possess immunomodulatory effects to enhance macrophages-mediated osteogenesis and antibacterial activity. Moreover, the DA-Cu II coated PEEK induced a mild and necessary inflammatory response, exhibiting excellent antibacterial ability and superior osseointegration. Our findings suggest that DA-Cu II coated PEEK has excellent potential for orthopedic implants and provides new insight into novel modification strategies of PEEK materials. ? 2022, The Authors. All rights reserved.