文献类型：期刊文献

英文题名：Donkey genomes provide new insights into domestication and selection for coat color

作者：Wang, Changfa[1,2];Li, Haijing[3];Guo, Yu[4];Huang, Jinming[1];Sun, Yan[1];Min, Jiumeng[4];Wang, Jinpeng[1];Fang, Xiaodong[4];Zhao, Zicheng[5];Wang, Shuai[5];Zhang, Yanlin[5];Liu, Qingfeng[4];Jiang, Qiang[1];Wang, Xiuge[1];Guo, Yijun[1];Yang, Chunhong[1];Wang, Yinchao[3];Tian, Fang[3];Zhuang, Guilong[1];Fan, Yanna[1];Gao, Qican[1];Li, Yuhua[2];Ju, Zhihua[1];Li, Jianbin[1];Li, Rongling[1];Hou, Minghai[1];Yang, Guiwen[6];Liu, Guiqin[2];Liu, Wenqiang[2];Guo, Jiao[7];Pan, Shanshan[7];Fan, Guangyi[7];Zhang, Wei[1];Zhang, Ruitao[2];Yu, Jie[3];Zhang, Xinhao[3];Yin, Qi[4];Ji, Chuanliang[3];Jin, Yuanchun[4];Yue, Guidong[4];Liu, Mei[8];Xu, Jiake[9];Liu, Shimin[10];Jordana, Jordi[10];Noce, Antonia[10,11];Amills, Marcel[10,11];Wu, Dong Dong[12,13];Li, Shuaicheng[5];Zhou, Xiangshan[3,14];Zhong, Jifeng[1,15]

机构：[1]Shandong Acad Agr Sci, Dairy Cattle Res Ctr, Jinan 250100, Peoples R China;[2]Liaocheng Univ, Liaocheng Res Inst Donkey High Efficiency Breedin, Liaocheng 252059, Shandong, Peoples R China;[3]Dong EE Jiao Co Ltd, Natl Engn Res Ctr Gelatin Based Tradit Chinese Me, Liaocheng 252201, Shandong, Peoples R China;[4]BGI Shenzhen, Shenzhen 252201, Peoples R China;[5]City Univ Hong Kong, Dept Comp Sci, Hong Kong 999077, Peoples R China;[6]Shandong Normal Univ, Coll Life Sci, Jinan 250000, Peoples R China;[7]BGI Shenzhen, BGI Qingdao, Qingdao 266555, Peoples R China;[8]Nanjing Normal Univ, Jiangsu Key Lab Mol & Med Biotechnol, Nanjing 210023, Peoples R China;[9]Univ Western Australia, Sch Biomed Sci, M508,35 Stirling Hwy, Perth, WA 6009, Australia;[10]Univ Autonoma Barcelona, Fac Vet, Dept Ciencia Anim Aliments, Bellaterra 08193, Spain;[11]CSIC IRTA UAB UB, Ctr Res Agr Genom CRAG, Dept Anim Genet, Campus Univ Autonoma Barcelona, Bellaterra 08193, Spain;[12]Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China;[13]Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China;[14]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[15]Jiangsu Acad Agr Sci, Inst Anim Sci, Nanjing 210014, Peoples R China

年份：2020

卷号：11

期号：1

外文期刊名：NATURE COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000608836600001)】；

基金：We would like to thank the numerous donkey owners who provided the samples analyzed in our study. This work was supported by the National Natural Science Foundation of China (grant nos. 31671287 and 31601007), Agricultural Science and Technology Innovation Project of Shandong Academy of Agricultural Sciences (grant no. CXGC2016C02), Well-bred Program of Shandong Province (grant no. 2017LZGC020), Joint Innovation Funds of Dong E. E. Jiao and Shandong Academy of Agricultural Sciences, Taishan Leading Industry Talents-Agricultural Science of Shandong Province (grant no. LJNY201713), and Shandong Province Modern Agricultural Technology System Donkey Industrial Innovation Team (grant no. SDAIT-27).

语种：英文

摘要：Current knowledge about the evolutionary history of donkeys is still incomplete due to the lack of archeological and whole-genome diversity data. To fill this gap, we have de novo assembled a chromosome-level reference genome of one male Dezhou donkey and analyzed the genomes of 126 domestic donkeys and seven wild asses. Population genomics analyses indicate that donkeys were domesticated in Africa and conclusively show reduced levels of Y chromosome variability and discordant paternal and maternal histories, possibly reflecting the consequences of reproductive management. We also investigate the genetic basis of coat color. While wild asses show diluted gray pigmentation (Dun phenotype), domestic donkeys display non-diluted black or chestnut coat colors (non-Dun) that were probably established during domestication. Here, we show that the non-Dun phenotype is caused by a 1bp deletion downstream of the TBX3 gene, which decreases the expression of this gene and its inhibitory effect on pigment deposition. A new donkey reference genome and comparisons with wild asses yields insights into the evolutionary history of donkey domestication and identifies a genetic variant that results in the non-Dun coat colours of domestic donkeys.