文献类型：期刊文献

英文题名：Enantioselective Cascade Reaction of -Cyano Ketones and Isatylidene Malononitriles: Asymmetric Construction of Spiro[4H-pyran-oxindoles]

作者：Xie, Jin[1,2];Xing, Wei-Long[1,2];Sha, Feng[1,2];Wu, Xin-Yan[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2016

卷号：2016

期号：23

起止页码：3983

外文期刊名：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000382962700011)，CCR-EXPANDED(收录号:WOS:000382962700011)】；

基金：The authors are grateful for financial support from the National Natural Science Foundation of China (NSFC) (grant number 21102043), the Science and Technology Commission of Shanghai Municipality (grant number 15ZR1409200), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Organocatalysis; Asymmetric catalysis; Domino reactions; Spiro compounds; Nitrogen heterocycles

摘要：-Cyano ketones have been employed for the first time as Michael donors in the construction of chiral spiro compounds. By using only 2 mol-% of a chiral multifunctional organocatalyst, chiral spiro[4H-pyran-oxindole] derivatives were prepared in yields of 97-99% with enantioselectivities of 76-97%ee. This method provides a new approach to the synthesis of chiral spirocyclic oxindoles.