文献类型：期刊文献

英文题名：Synergistic Catalysis for Asymmetric [3+2] Cycloadditions of 2-Indolylmethanols with α,β-Unsaturated Aldehydes

作者：Mao, Jia;Zhang, Hao;Ding, Xiang-Feng;Luo, Xiaoyan[1];Deng, Wei-Ping[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2019

卷号：84

期号：17

起止页码：11186

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20193607401833);WOS:【SCI-EXPANDED(收录号:WOS:000485089200062)，CCR-EXPANDED(收录号:WOS:000485089200062)】；

基金：This work is supported by the National Natural Science Foundation of China (No. 21572053) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Aldehydes - Cycloaddition - Palladium compounds

摘要：A catalytic asymmetric [3 + 2] cycloaddition of 2-indolylmethanols with alpha,beta-unsaturated aldehydes was developed for the first time. This transformation was achieved by a synergistic catalytic system consisting of a palladium complex, a Bronsted acid, and a chiral secondary amine to synthesize biologically active cyclopenta[b]indole derivatives with excellent diastereo- and enantioselectivities (up to >20:1 dr, up to 99% ee).