文献类型：期刊文献

英文题名：Enantioselective Liquid-Liquid Extraction of Zopiclone With Mandelic Acid Ester Derivatives

作者：Peng, Yangfeng[1];He, Quan[2];Zuo, Bin[1];Niu, Haibo[2];Tong, Tianzhong[1];Zhao, Hongliang[1]

机构：[1]E China Univ Sci & Technol, Dept Chem Engn, Shanghai 200237, Peoples R China;[2]Dalhousie Univ, Dept Engn, Fac Agr, Truro, NS B2N 5E3, Canada

年份：2013

卷号：25

期号：12

起止页码：952

外文期刊名：CHIRALITY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000327312400017)】；

语种：英文

外文关键词：enantioselective extraction; enantiomer; zopiclone; mandelic acid ester; chiral recognition

摘要：Enantioselective liquid-liquid extraction of zopiclone was conducted by employing a series of (R)-mandelic acid esters as chiral extractants. The effects of concentration of extractant, concentration of zopiclone, type of organic solvent, pH value, and temperature on the extraction efficiency were investigated. (R)-o-chloromandelic acid propyl ester was demonstrated to be an efficient chiral extractant for zopiclone resolution with a maximum enantioselectivity of 1.6. Chirality 25:952-956, 2013. (c) 2013 Wiley Periodicals, Inc.