文献类型：期刊文献

英文题名：Antioxidant Properties of Polysaccharide from the Brown Seaweed Sargassum graminifolium (Turn.), and Its Effects on Calcium Oxalate Crystallization

作者：Zhang, Chao-Yan[1,2];Wu, Wen-Hui[2];Wang, Jue[2];Lan, Min-Bo[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Res Ctr Anal & Testing, Shanghai 200237, Peoples R China;[2]Shanghai Ocean Univ, Inst Marine Sci, Coll Food Sci & Technol, Shanghai 201306, Peoples R China

年份：2012

卷号：10

期号：1

起止页码：119

外文期刊名：MARINE DRUGS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000299541800009)】；

基金：The authors thank Wenhui Wu (Institute of Marine Sciences, Shanghai Ocean University) for assistance with the microscopic analysis. This study was supported by the National 863 Plans Projects of China (2011AA09070109).

语种：英文

外文关键词：calcium oxalate crystallization; antioxidant; polysaccharide; Sargassum graminifolium

摘要：We investigated the effects of polysaccharides from the brown seaweed Sargassum graminifolium (Turn.) (SGP) on calcium oxalate crystallization, and determined its antioxidant activities. To examine the effects of SGP on calcium oxalate crystallization, we monitored nucleation and aggregation of calcium oxalate monohydrate crystals, using trisodium citrate as a positive control. We assessed antioxidant activities of SGP by determining its reducing power, its ability to scavenge superoxide radicals, and its activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The nucleation inhibition ratio of trisodium citrate and SGP was 58.5 and 69.2%, respectively, and crystal aggregation was inhibited by 71.4 and 76.8%, respectively. Increasing concentrations of SGP resulted in increased scavenging of superoxide anions and DPPH radicals (IC50 = 1.9 and 0.6 mg/mL, respectively). These results suggest that SGP could be a candidate for treating urinary stones because of its ability to inhibit calcium oxalate crystallization and its antioxidant properties.