文献类型：期刊文献

英文题名：Adenosine capped QDs based fluorescent sensor for detection of dopamine with high selectivity and sensitivity

作者：Mu, Qin[1];Xu, Hu[1];Li, Yan[1];Ma, Shijian[1];Zhong, Xinhua[1]

机构：[1]E China Univ Sci & Technol, Dept Chem, Inst Appl Chem, Shanghai 200237, Peoples R China

年份：2014

卷号：139

期号：1

起止页码：93

外文期刊名：ANALYST

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000327548400012)】；

基金：This work was supported by Chenguang Program of the Shanghai Education Commission (11CG31), the National Natural Science Foundation of China (no. 21175043), the Fujian Provincial Key Laboratory of Nanomaterials (NM10-06), the Science and Technology Commission of Shanghai Municipality (11JC1403100, 12NM0504101), and the Fundamental Research Funds for the Central Universities.

语种：英文

摘要：Facile detection of dopamine (DA) in biological samples for diagnostics remains a challenge. This paper reported an effective fluorescent sensor based on adenosine capped CdSe/ZnS quantum dots (A-QDs) for highly sensitive detection of DA in human urine samples. In this assay, adenosine serves as a capping ligand or stabilizer for QDs to render high-quality QDs dispersed in water, and as a receptor for DA to attach DA onto the surface of A-QDs. DA molecules can bind to A-QDs via non-covalent bonding, leading to the fluorescence quenching of A-QDs due to electron transfer. The A-QDs based fluorescence probe showed a limit of detection (LOD) of ca. 29.3 nM for DA detection. This facile method exhibited high selectivity and anti-interference in the presence of amino acid, ascorbic acid (AA), uric acid (UA) and glucide with 100-fold higher concentration in PBS solution. Furthermore, it was also successfully used in the detection of DA in the human urine samples with quantitative recoveries (94.80-103.40%).