文献类型：期刊文献

英文题名：Diastereoselective Synthesis of Bicyclo[2.2.2]octan-2-one Derivatives through an Unexpected Organocatalytic Tandem Michael-Michael Reaction

作者：Yang, Juanjuan[1];Huang, Huicai[1];Jin, Zhichao[1];Wu, Wenbin[1];Ye, Jinxing[1]

机构：[1]E China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Sch Pharm, Shanghai 200237, Peoples R China

年份：2011

期号：12

起止页码：1984

外文期刊名：SYNTHESIS-STUTTGART

收录：;EI(收录号：20112414053524);WOS:【SCI-EXPANDED(收录号:WOS:000291302900023)，CCR-EXPANDED(收录号:WOS:000291302900023)】；

基金：We are grateful for the financial support of this work from the Innovation Program of Shanghai Municipal Education Commission (11ZZ56), the National Natural Science Foundation of China (20902018), the Shanghai Pujiang Program (08PJ1403300) and from the Fundamental Research Funds for Central Universities.

语种：英文

外文关键词：organocatalysis; Michael reaction; tandem reaction; alpha,beta-unsaturated ketones

摘要：An organocatalytic tandem Michael-Michael reaction is developed for the simple preparation of stereo complex, polycyclic compounds from simple reactants in satisfactory yields (up to 90%) and excellent diastereoselectivities (>30:1 dr).