文献类型：期刊文献

英文题名：Recent advances of multi-dimensional porphyrin-based functional materials in photodynamic therapy

作者：Tian, Jia[1];Huang, Baoxuan[1];Nawaz, Mian Hasnain[2];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Sch Chem & Mol Engn, Meilong Rd 130, Shanghai 200237, Peoples R China;[2]COMSATS Univ Islamabad, Interdisciplinary Res Ctr Biomd Mat, Lahore Campus, Lahore 54000, Pakistan

年份：2020

卷号：420

外文期刊名：COORDINATION CHEMISTRY REVIEWS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000551658600008)】；

基金：This work was financially supported by the National Natural Science Foundation of China (No. 51803058 and 21875063) and the Fundamental Research Funds for the Central Universities (No. 222201814018).

语种：英文

外文关键词：Porphyrin; Photodynamic therapy; Singlet oxygen; Block copolymer; Supramolecular polymer

摘要：Photodynamic therapy (PDT) has emerged as a promising and non-invasive modality for cancer treatments. Photosensitizers, as one of the essential elements in PDT, play a crucial role in the practical applications of PDT. Exposure to suitable light irradiation leads these photosensitizers to absorb the energy and move to excited state. Eventually, they transfer the energy to surrounding molecules and produce reactive oxygen species (ROS), particularly the singlet oxygen (O-1(2)). Porphyrins, consisting of tetrapyrrole bridged with four methylene groups, are the classical and typical photosensitizers. However, the poor water-solubility, low biostability and non-specific tumor-targeting properties of porphyrins limit the PDT efficiency and their clinical applications. Thus, in order to promote the PDT efficiency of porphyrins, a variety of modification and functionalization strategies have been developed to construct multi-dimensional porphyrin-based functional materials. Herein, we summarize the recent advances of porphyrin-based functional materials from the following aspects: (1) the porphyrinic amphiphiles, (2) physical encapsulation of porphyrins by nanoparticles, (3) the construction of porphyrin-based polymers including block copolymers with covalent bonding and supramolecular polymers with non-covalent bonding, and (4) porphyrin-based organic frameworks. We believe that the development of porphyrin-based functional materials provide more fascinating superiorities in PDT and dramatically expand the potentials and possibilities in cancer treatments. (C) 2020 Elsevier B.V. All rights reserved.