文献类型：期刊文献

英文题名：Enhanced bioreduction-responsive biodegradable diselenide-containing poly(ester urethane) nanocarriers

作者：Wei, Chao[1];Zhang, Yan[1];Song, Zhongchen[2];Xia, Yiru[2];Xu, Heng[3];Lang, Meidong[1]

机构：[1]East China Univ Sci & Technol, Sch Mat & Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Peoples Hosp 9, Sch Med, Dept Periodontol,Shanghai Key Lab Stomatol,Minist, Shanghai 200237, Peoples R China;[3]Collaborat Innovat Ctr Petrochem New Mat, Anqing 246011, Anhui, Peoples R China

年份：2017

卷号：5

期号：4

起止页码：669

外文期刊名：BIOMATERIALS SCIENCE

收录：;EI(收录号：20171403516736);WOS:【SCI-EXPANDED(收录号:WOS:000399002000006)】；

基金：Financial support from the National Natural Science Foundation of China (21274039), the Shanghai Pujiang Program (14PJD014), the 111 Project (B14018), the Specialized Research Fund for the Doctoral Program of Higher Education (20130074110007) and the National Key Research and Development Program (2016YFC1100700) is gratefully acknowledged.

语种：英文

外文关键词：Controlled drug delivery - Selenium compounds - Biocompatibility - Degradation - Esters - Sulfur compounds - Drug products - Targeted drug delivery

摘要：Stimuli-responsive nanocarriers have been limited for bench-to-bedside translation mainly because the stimuli sensitivity and responsive rate are not high enough to ensure sufficient drug concentration at the target sites for superior therapeutic benefits. Herein, we reported an enhanced bioreduction-responsive and biodegradable nanocarrier based on the amphiphilic poly(ester urethane) copolymers (PAUR-SeSe) bearing multiple diselenide groups on the backbone. The copolymer could spontaneously self-assemble into stable micelles in aqueous medium with an average diameter of 68 nm, which could be rapidly disassembled in a reductive environment as a result of the reduction-triggered cleavage of diselenide groups. Furthermore, the PAUR-SeSe micelles showed an enhanced drug release profile and cellular uptake compared with the disulfide-containing analogue (PAUR-SS). CCK8 assays revealed that the antitumor activity of DOX-loaded PAUR-SeSe micelles was much higher than that of DOX-loaded PAUR-SS micelles. Besides, the blank micelles and degradation products were nontoxic up to a tested concentration of 50 mu g mL(-1). Therefore, the enhanced therapeutic efficacy and good biocompatibility demonstrated that this drug nanocarrier had great potential for smart antitumor drug delivery applications.