文献类型：期刊文献

英文题名：Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization

作者：Wu, Yueming[1,2];Chen, Kang[1];Wang, Jiangzhou[1];Chen, Minzhang[1];Dai, Wenhui[1];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, Minist Educ, Sch Mat Sci & Engn, Key Lab Ultrafine Mat,Key Lab Specially Funct Poly, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2024

卷号：146

期号：35

起止页码：24189

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;EI(收录号：20243516933575);WOS:【SCI-EXPANDED(收录号:WOS:001296674900001)】；

基金：This research was supported by the National Natural Science Foundation of China (No. T2325010, 52203162, 22075078, 52361165622), the National Key Research and Development Program of China (2022YFC2303100), Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission). The authors also thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization for studies reviewed in this manuscript.

语种：英文

摘要：Polypeptides have the same or similar backbone structures as proteins and peptides, rendering them as suitable and important biomaterials. Amino acid N-carboxyanhydrides (NCA) ring-opening polymerization has been the most efficient strategy for polypeptide preparation, with continuous advance in the design of initiators, catalysts and reaction conditions. This Perspective first summarizes the recent progress of NCA synthesis and purification. Subsequently, we focus on various initiators for NCA polymerization, catalysts for accelerating polymerization or enhancing the controllability of polymerization, and recent advances in the reaction approach of NCA polymerization. Finally, we discuss future research directions and open challenges.