文献类型：期刊文献

英文题名：Facile Access to Piezoelectric Polyamides by Polyamidation of Carboxylic Acids and Ynamides for Potent Tumor Immunotherapy

作者：Li, Xingguang[1,2,3];Yan, Ruiqi[4];Tan, Mei[1];Kwok, Ryan T. K.[2,3];Sun, Jianwei[1];Xiang, Huijing[4];Ma, Xiang[1];Lam, Jacky W. Y.[2,3];Tang, Ben Zhong[2,3,5]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Key Lab Adv Mat,Shanghai Key L, Shanghai 200237, Peoples R China;[2]Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recons, Div Life Sci, Dept Chem,State Key Lab Mol Neurosci,Hong Kong Bra, Clear Water Bay, Hong Kong 997077, Peoples R China;[3]Hong Kong Univ Sci & Technol, Dept Chem & Biol Engn, Kowloon, Clear Water Bay, Hong Kong 997077, Peoples R China;[4]Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China;[5]Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen CUHK Shenzhen, Shenzhen 518172, Guangdong, Peoples R China

年份：2025

卷号：64

期号：21

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20251418185935);WOS:【SCI-EXPANDED(收录号:WOS:001490317000024)】；

基金：The authors greatly acknowledge the final support of the National Natural Science Foundation of China (Grant No. T2322018, 22125803, 32171391, and 22201073), Shanghai Rising-Star Program (Grant No. 22QA1403600), the Fundamental Research Funds for the Central Universities, the Innovation and Technology Commission (ITC-CNERC14SC01 and ITCPD/17-9), Shenzhen Key Laboratory of Functional Aggregate Materials (ZDSYS20211021111400001), and the Science Technology Innovation Commission of Shenzhen Municipality (2023YFB3810001, KQTD20210811090142053 and JCYJ20220818103007014). The authors also thank the Research Center of Analysis and Test of East China University of Science and Technology for help in the characterization. The schematic illustration is created with BioRender.com.

语种：英文

外文关键词：Aggregation-induced emission; Piezoelectric effect; Polyamides; Reactive oxygen species; Tumor therapy

摘要：Polyamides are a fascinating group of piezoelectric materials that are largely synthesized by the polycondesation of dicarboxylic acids with diamines or the ring-opening polymerization of special lactams. However, developing a green polymerization approach for the facile synthesis of piezoelectric polyamides is highly desirable but also challenging. Here, a simple polyamidation of carboxylic acids and ynamides is successfully established to synthesize versatile piezoelectric polyamides. This polymerization also possesses the merits of 100% atom economy, no waste generation, and additive-free as well as catalyst-free system. A range of polyamides are synthesized in moderate to good yields with satisfactory molecular weights. Importantly, piezoelectric polyamides containing tetraphenylethene (P1e/2b) can generate a bundant reactive oxygen species under ultrasound (US) exposure, thereby eliciting robust immunogenic cell death induction for augmented piezoelectric immunotherapy. Furthermore, P1e/2b exhibits distinctive aggregation-induced emission property that allows fluorescence imaging. In vivo evaluation using a bilateral tumor-bearing mouse model manifested that P1e/2b administration reinforced systemic immunity and triggered immune memory under US exposure, thereby leading to primary tumor eradication and distant tumor suppression. Therefore, this work represents a transition-metal-free and waste-free polymerization paradigm for the construction of piezoelectric polyamides, providing a distinct strategy to designing new piezoelectric polymers for effective tumor immunotherapy.