文献类型：期刊文献

英文题名：Synthesis of Versatile Aryliodine Synthons by Aryliodonium Rearrangement Reactions

作者：Pan, Cheng[1,2,3];Wang, Limin[1,2,3];Han, Jianwei[1,2,3]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Dept Fine Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Inst Fine Chem, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2024

卷号：13

期号：7

外文期刊名：ASIAN JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001241598400001)】；

基金：The work was supported by the Natural Science Foundation of Shanghai (20ZR1413500) and Industrial Support Projects with Ruicheng technology company.

语种：英文

外文关键词：aryliodonium salts; rearrangement reactions; aryliodine; synthetic methodology

摘要：The excellent reactivity of diaryliodonium salts has primarily been attributed to the efficient departure of the iodoarene unit, facilitating a variety of arylation reactions. However, one equivalent of iodoarene as a side-product is a chemical waste in these reactions, which was criticized by chemists for hindering its popularity. Recently, the development of synthetic methodology that preserve the aryl iodine moiety received increasing attention. Oxidative rearrangement reactions involving aryliodonium reagents have significantly addressed the atom-economic issue, thereby broadening the reaction scope. The resulting intricate aryliodine products are viewed as valuable synthons for the synthesis of natural products, pharmaceutical intermediates and other fine chemicals. The unique reactivity of aryliodonium salts primarily stems from the excellent leaving ability of aryliodine moiety. Traditional arylations with aryliodonium reagents have rarely involves retaining the iodine group in the final products. Recently, rearrangement reactions that preserve the aryliodine moiety have significantly broadened the scope of aryliodonium applications, opening a way for the preparing synthetically important aryliodide synthons. These synthons have been extensively employed in the synthesis of natural products and pharmaceutical intermediates. image