文献类型：期刊文献

英文题名：Chemo-Enzymatic Synthesis of Poly(4-piperidine lactone- b-ω-pentadecalactone) Block Copolymers as Biomaterials with Antibacterial Properties

作者：Xiao, Yan[1]; Pan, Jinghao[1]; Wang, Dong[1]; Heise, Andreas[2]; Lang, Meidong[1]

机构：[1] Key Laboratory for Ultrafine Materials, Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China; [2] Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, St. Stephens Green, Dublin 2, Ireland

年份：2018

卷号：19

期号：7

起止页码：2673

外文期刊名：Biomacromolecules

收录：EI(收录号：20181905173849)

语种：英文

外文关键词：Esters - Ring opening polymerization - Medical applications - Escherichia coli - Block copolymers

摘要：With increasing troubles in bacterial contamination and antibiotic-resistance, new materials possessing both biocompatibility and antimicrobial efficacy are supposed to be developed for future biomedical application. Herein, we demonstrated a chemo-enzymatic ring opening polymerization (ROP) approach for block copolyester, that is, poly(4-benzyl formate piperidine lactone-b-ω-pentadecalactone) (PNPIL-b-PPDL), in a one-pot two-step process. Afterward, cationic poly(4-piperidine lactone-b-ω-pentadecalactone) (PPIL-b-PPDL) with pendent secondary amino groups was obtained via acidic hydrolysis of PNPIL-b-PPDL. The resulting cationic block copolyester exhibited high antibacterial activity against Gram negative E. coli and Gram positive S. aureus, while showed low toxicity toward NIH-3T3 cells. Moreover, the antibacterial property, cytotoxicity and degradation behavior could be tuned simply by variation of PPIL content. Therefore, we anticipate that such cationic block copolymers could potentially be applied as biomaterials for medicine or implants. Copyright ? 2018 American Chemical Society.