文献类型：期刊文献

英文题名：Copper-Catalyzed Trifluoromethylazidation of Alkynes: Efficient Access to CF3-Substituted Azirines and Aziridines

作者：Wang, Fei[1];Zhu, Na[1,2];Chen, Pinhong[1];Ye, Jinxing[2];Liu, Guosheng[1]

机构：[1]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc,Chem, Shanghai 200237, Peoples R China

年份：2015

卷号：54

期号：32

起止页码：9356

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20152600981498);WOS:【SCI-EXPANDED(收录号:WOS:000358621500039)，CCR-EXPANDED(收录号:WOS:000358621500039)】；

基金：We are grateful for financial support from the National Basic Research Program of China (No. 973-2015CB856600) and the National Natural Science Foundation of China (Nos. 21225210, 21202185, 21472219, and 21421091).

语种：英文

外文关键词：alkynes; copper; heterocycles; rearrangements; synthetic methods

摘要：A novel method for convenient access to CF3-containing azirines has been developed, and involves a copper-catalyzed trifluoromethylazidation of alkynes and a photocatalyzed rearrangement. Both terminal and internal alkynes are compatible with the mild reaction conditions, thus delivering the CF3-containing azirines in moderate to good yields. The azirines can be converted into various CF3-substituted aziridines.