文献类型：期刊文献

英文题名：An oxygen self-sufficient NIR-responsive nanosystem for enhanced PDT and chemotherapy against hypoxic tumors

作者：Yang, Guoliang[1];Tian, Jia[1];Chen, Chao[2];Jiang, Dawei[1];Xue, Yudong[1];Wang, Chaochao[1];Gao, Yun[1];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Key Lab Specially Funct Polymer Mat & Related Tec, Shanghai Key Lab Funct Mat Chem, Minist Educ, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn Ctr, Shanghai, Peoples R China

年份：2019

卷号：10

期号：22

起止页码：5766

外文期刊名：CHEMICAL SCIENCE

收录：;EI(收录号：20192407039674);WOS:【SCI-EXPANDED(收录号:WOS:000474413300011)】；

基金：This work was financially supported by the National Natural Science Foundation of China (No. 21574039 and 51803058) and Shanghai Sailing Program (No. 19YF1410900). All animal procedures were performed in accordance with Chinese legislation on the Use and Care of Research Animals (Document No. 55, 2001), and institutional guidelines for the Care and Use of Laboratory Animals established by the East China University of Science and Technology Animal Studies Committee, and this committee approved the experiments.

语种：英文

外文关键词：Oxygen - Photodynamic therapy - Tumors - Nanosystems - Targeted drug delivery - Glycoproteins - Infrared devices - Synthesis (chemical) - Nanoparticles - Cancer cells - Controlled drug delivery

摘要：The efficacy of photodynamic therapy and chemotherapy is largely limited by oxygen deficiency in the hypoxic tumor microenvironment. To solve these problems, we fabricated a novel NIR-responsive nanosystem which could co-deliver oxygen and anticancer drug DOX. An oxygen self-sufficient amphiphile (F-IR780-PEG) was first synthesized and subsequently utilized to load anticancer drug DOX to form nanoparticles (F/DOX nanoparticles). Due to the high oxygen capacity of such nanoparticles, the hypoxic tumor microenvironment was greatly modulated after these nanoparticles reached the tumor region, and the results revealed that hypoxia-inducible factor alpha (HIF-1 alpha) was down-regulated and the expression of P-glycoprotein (P-gp) was then reduced, which were in favor of chemotherapy. Under light irradiation at 808 nm, IR780 could efficiently produce singlet oxygen to damage cancer cells by photodynamic therapy (PDT). Simultaneously, the IR780 linkage could be cleaved by singlet oxygen generated by itself and resulted in DOX release, which further caused cell damage by chemotherapy. With the combination of PDT and chemotherapy, F/DOX nanoparticles showed remarkable therapeutic efficacy under in vitro and in vivo conditions. Furthermore, the F/DOX nanoparticles are favorable for imaging-guided tumor therapy due to the inherent fluorescence properties of IR780. We thus believe that the synergistic treatment described here leads to an ideal therapeutic approach to hypoxic tumors.