文献类型：期刊文献

英文题名：Access to α-Hydroxy Amides via a Practical Metal-Free "One-Pot" Tandem Reaction Involving Aerobic C(sp3)-H Hydroxylation and C(sp2)-C(sp3) Cleavage

作者：Zhang, Xiao[1,2];Yu, Yang[1,2];Li, Wenjie[1,2];Shi, Lei[3];Li, Hao[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[3]Dohler Food & Beverage Ingredients Shanghai Co Ltd, Shanghai 201108, Peoples R China

年份：2022

卷号：87

期号：24

起止页码：16263

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20225013229150);WOS:【SCI-EXPANDED(收录号:WOS:000893098000001)，CCR-EXPANDED(收录号:WOS:000893098000001)】；

基金：ACKNOWLEDGMENTS This work was supported by the program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institu-tions of Higher Learning (GZ2017007) , the China 111 Project (Grant B07023) .

语种：英文

外文关键词：Amides

摘要：A flexible metal-free cascade reaction involving aerobic C(sp(3))-H hydroxylation and decarbonylation with high regioselectivity and functional group tolerance has been established. Moreover, this indirect hydroxylation approach of N-aryl amides could enable the construction of a wide range of valuable secondary alcohols at a-position of N-aryl amides. It provides a supplementary strategy for direct alpha-hydroxylation of simple amides.