文献类型：期刊文献

英文题名：Metal-Free Boron-Mediated ortho-C-H Hydroxylation of N-Benzyl-3,4,5-tribromopyrazoles

作者：Wu, Gaorong[1];Yang, Zhaoziyuan[1];Xu, Xiaobo[1];Hao, Liqiang[1];Chen, Lu[1];Wang, Yangyang[1];Ji, Yafei[1]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Minist Educ, Shanghai 200237, Peoples R China

年份：2022

卷号：24

期号：19

起止页码：3570

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000800665700026)，CCR-EXPANDED(收录号:WOS:000800665700026)】；

基金：We gratefully thank the National Natural Science Foundation of China (Project No. 21676088) for financial support.

语种：英文

摘要：A novel route has been reported for C-H hydroxylation of benzyl compounds directed by a 3,4,5-tribromopyrazole auxiliary via boronation/oxidation using BBr3 and NaBO3 center dot 4H(2)O. The strategy exhibits outstanding site selectivity and affords the corresponding phenols in moderate to excellent yields under metal-free conditions. Besides, this protocol can be achieved in one pot, which is highly promising as a practical method for use in a multistep organic synthetic process.