文献类型：期刊文献

英文题名：Enantioselective synthesis of 3-amino-hydrobenzofuran-2,5-diones via Cu(i)-catalyzed intramolecular conjugate addition of imino esters

作者：Yang, Wu-Lin[1];Sun, Zhong-Tao[2];Zhang, Jian[2];Li, Zhong[1,3];Deng, Wei-Ping[2]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Shanghai Collaborat Innovat Ctr Biomfg Technol, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2019

卷号：6

期号：5

起止页码：579

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：;EI(收录号：20191006586300);WOS:【SCI-EXPANDED(收录号:WOS:000459735400001)，CCR-EXPANDED(收录号:WOS:000459735400001)】；

基金：This work is supported by the National Natural Science Foundation of China (No. 21772038), the Fundamental Research Funds for the Central Universities, the China Postdoctoral Science Foundation (No. 2018M632037), and the Shanghai Sailing Program (No. 18YF140560).

语种：英文

外文关键词：Enantioselectivity - Copper compounds - Ketones

摘要：A highly enantioselective intramolecular conjugate addition of imino esters was presented. By employing cyclohexadienone-tethered imino esters, enantioenriched 3-amino-hydrobenzofuran-2,5-dione skeletons bearing three contiguous stereocenters were synthesized via the desymmetrization of prochiral cyclohexadienones. Notably, bicyclic cyclohexenones bearing up to three vicinal quaternary stereocenters could be constructed in a single step by this strategy.